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San Francisco 49ers
Current projected depth order. Injury labels come from current roster observations, or the depth chart when current roster status is unavailable. No status is inferred from depth.
Offense
| Position | Starter | Second | Third | Fourth |
|---|---|---|---|---|
| QB | Brock Purdy | Mac Jones | Kurtis Rourke | — |
| WR | Mike EvansOUT | Brandin Cooks | Demarcus RobinsonIR | Brandon AiyukOUT |
| WR | Deebo Samuel Sr.OUT | Christian Kirk | De'Zhaun StriblingIR | — |
| WR | Jordan Watkins | Jacob Cowing | Ricky PearsallIR | — |
| LT | Trent Williams | Vederian Lowe | Enrique Cruz Jr. | Austen PleasantsIR |
| LG | Connor Colby | Carver Willis | Nick ZakeljIR | — |
| C | Jake Brendel | Jarrett Patterson | — | — |
| RG | Dominick Puni | Carver Willis | — | — |
| RT | Colton McKivitz | Enrique Cruz Jr. | — | — |
| TE | George Kittle | Luke Farrell | Brayden Willis | Jake TongesIR |
| RB | Christian McCaffrey | Kaelon Black | Jordan James | Isaac GuerendoOUT |
| FB | Kyle Juszczyk | — | — | — |
Defense
| Position | Starter | Second | Third | Fourth |
|---|---|---|---|---|
| LDE | Keion White | Romello Height | Khalid Kareem | Sam OkuayinonuIR |
| LDT | Osa Odighizuwa | Sebastian Valdez | C.J. WestIR | — |
| RDT | Gracen Halton | James Thompson Jr. | Alfred CollinsIR | — |
| RDE | Nick BosaOUT | Mykel Williams | Ogbo Okoronkwo | Andrew Farmer IIIR |
| WLB | Dre Greenlaw | Garret WallowOUT | Jalen Graham | — |
| MLB | Fred Warner | Tatum Bethune | Nick MartinIR | — |
| SLB | Jaden Dugger | Luke GiffordOUT | — | — |
| LCB | Renardo Green | Jack Jones | — | — |
| SS | Marques SigleOUT | Malik Mustapha | Siran Neal | — |
| FS | Ji'Ayir Brown | Ashtyn Davis | Darrick ForrestIR | — |
| RCB | Deommodore Lenoir | Ephesians Prysock | Nate HobbsIR | — |
| NB | Upton Stout | Ashtyn Davis | — | — |